Atlantic Coast Conference teams started 8-2 in NCAA baseball regionals Friday, with Clemson hitting a tournament record seven home runs in its victory, defending national champion Virginia winning easily and Duke getting hammered in its first appearance in 55 years.

Chris Okey and Mike Triller hit two homers apiece for No. 7 national seed Clemson, which routed Western Carolina 24-10 in Clemson, South Carolina. Half of Clemson's 14 hits were home runs, and seven Catamounts pitchers combined to issue 17 walks.

Virginia set a school tournament record with 20 hits and scored at least one run in the second through eighth innings to beat William & Mary 17-4 in Charlottesville, Virginia.

No. 2 national seed Louisville and No. 3 Miami also gave the ACC wins, as did Florida State, Wake Forest, Boston College and North Carolina State.

Duke, which hadn't appeared in the NCAA Tournament since 1961, lost 11-1 to UNC-Wilmington. Georgia Tech accounted for the ACC's other loss, 7-6 to UConn.

The ACC set a league record with 10 teams in the field.

A look around the country:

UPSETS OF DAY

No. 4 regional seeds Rhode Island and Utah pulled the biggest surprises.

The Rams knocked off host South Carolina 5-4, led by Tyler Wilson's 11 strikeouts over seven innings and Brett McManus' home run and three RBIs. The Gamecocks managed only six hits against Wilson and two relievers, and coach Chad Holbrook was ejected in the seventh inning.

The Utes beat Mississippi 6-5, with Hunter Simmons' single driving in pinch runner Chandler Anderson in the top of the 10th inning after Anderson had moved up to second base on a passed ball. Ole Miss had runners on first and second with one out in the bottom half, but Dylan Drachler got the last two outs.

GAME OF DAY

Austin Bush homered leading off the bottom of the 14th inning, giving UC Santa Barbara a 3-2 win over Washington in Nashville, Tennessee.

The Gauchos had runners on second base in each of the previous three innings before Bush drove Alex Nesbitt's 1-1 pitch deep over the right-field fence to end the 4-hour, 45-minute game.

Washington went up 2-1 in the 12th on a bases-loaded walk, but Devon Gradford homered leading off the bottom half to tie it.

STREAK ENDS

Alabama State's Joseph Comacho, who was unbeaten in his last 36 starts (31-0) since February 2014, didn't make it out of the first inning in an 18-6 loss to Florida State in Tallahassee, Florida.

MARVELOUS ON MOUND

— Long Beach State's Chris Mathewson took a no-hitter into the seventh inning, and he and three relievers limited Florida Atlantic to three hits in a 5-1 win in Miami.

— Southern Mississippi's Kirk McCarty retired the first 14 South Alabama batters and gave up three singles over six innings in a 14-2 win in Tallahassee.

— East Carolina's Evan Kruczynski combined with three relievers on 8 1/3 shutout innings in a 9-1 win over Bryant in Charlottesville. Bryant entered the game sixth nationally in scoring at 8.1 runs a game.

BIG HITTERS

— Peter Alonso, out since May 13 with a broken left hand, homered twice and went 3 for 4 with three RBIs in No. 1 national seed Florida's 9-3 win over Bethune-Cookman in Gainesville, Florida.

— Preston Palmeiro, Andrew Knizner, Brett Kinneman and Josh McLain each homered in North Carolina State's seven-run fifth inning in a 13-8 win over Navy. Chance Shepard also hit a grand slam for the Wolfpack.

— Brent Rooker hit two homers and drove in four runs in No. 6 national seed Mississippi State's 9-5 victory over Southeast Missouri State in Starkville, Mississippi.

— Dylan Busby had a double and triple while going 3 for 6 with five RBIs for Florida State.

— Luis Gonzalez doubled three times, went 4 for 4 and had five RBIs in New Mexico's 12-6 win over Dallas Baptist in Lubbock.

DRAFT PROSPECT WATCH

— Corey Ray went 3 for 5 and stole three bases in No. 2 national seed Louisville's 6-1 win over Western Michigan in Louisville, Kentucky.

— Boston College's Justin Dunn struck out 11 over seven innings in the Eagles' 7-2 win over Tulane in Oxford, Mississippi.

— Two-way star Will Craig came on with one out and a man on first in the bottom of the ninth and induced two groundouts for his ninth save in Wake Forest's win over Minnesota in College Station, Texas.

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AP Sports Writer Pete Iacobelli in Columbia, South Carolina, contributed to this report.