COLUMBIA, Mo. — The last reigning Heisman Trophy winner to visit Columbia was Oklahoma's Billy Sims in 1979.
He did not repeat, and No. 6 Missouri made it unlikely Texas A&M quarterback Johnny Manziel wins a second Heisman trophy this year.
Missouri beat No. 21 Texas A&M 28-21 on Saturday night.
BOX SCORE: No. 6 Missouri 28, No. 21 Texas A&M 21
A 57-yard touchdown run by Missouri junior Henry Jose put the Tigers up 28-21 with 3:34 to play. He completed a 3-play, 66-yard drive that spanned just 1 minute, 13 seconds.
Manziel got the ball back, but he was not able to get a first down.
The Tigers' win made them the Southeastern Conference East Division champion. Missouri faces Auburn on Dec. 7 in Atlanta in the Southeastern Conference Championship.
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A 98-yard drive by A&M got the Aggies even at 21-21 in the fourth quarter. The biggest plays were Manziel passes to Travis Labhart for 24 and 14 yards along with runs by Trey Williams for 25 and 18 yards. The drive ended with a 7-yard touchdown run by Ben Malena at 10:43 to play.
This was after a third-quarter rally by Missouri saw the Tigers score twice to lead 21-14 entering the fourth quarter. A two-yard touchdown run by Marcus Murphy completed the opening drive of the second half, and it tied the game at 14.
The second touchdown took a review before the Missouri fans celebrated the 5-yard catch L'Damian Washington made on his back. Missouri went up 21-14.
Missouri's defense held A&M to three first downs and 54 total third-quarter yards after the Aggies had 11 first downs and 226 first-half total yards.
In the first half, Manziel guided the Aggies' offense to two touchdowns and a 14-7 halftime lead. He completed 12-of-16 first-half passes for 124 yards, including a 32-yard pass to Derel Walker that put the Aggies up 14-7 with 4:06 left in the first half. The other A&M first-half touchdown came on a 29-yard run by Tra Carson in the first quarter.
Missouri temporarily tied the game on a 38-yard pass from James Franklin to Dorial Green-Beckham with 5 minutes, 16 seconds left in the first half.