(SportsNetwork.com) - An 18-point deficit and no Reggie Wayne seemed to spell doom for the Indianapolis Colts last weekend.
For Andrew Luck and T.Y. Hilton, difficult took about 20 minutes to overcome.
The young Colts duo aim to lead their club to a third straight victory this Sunday when they play host to the struggling St. Louis Rams.
Indianapolis came out of its bye week with no Wayne, having lost the star wide receiver to a season-ending to a torn ACL in an Oct. 20 victory over Denver, and trailed by a 24-6 margin with 4:25 to play in the third quarter of a road game versus the rival Houston Texans.
That is when Luck and Hilton went to work, with the tandem hooking up for three touchdowns over the final quarter-plus of action, including the go-ahead nine-yard score with 4:00 minutes remaining.
Luck also hooked up with Hilton for touchdowns of 10 and 58 yards to complete a comeback that tied for the sixth-largest in franchise history.
"It's football. Anything happens, sometimes. That's why you have halftime and we were able to come in here and make corrections," noted Indy safety Antoine Bethea.
Luck threw for 271 yards, while Hilton tied a single-game franchise record with his three receiving touchdowns. He finished with a career-high seven receptions for 121 yards.
Tight end Coby Fleener added three receptions for 64 yards and also caught a two-point conversion pass following Hilton's third TD, while linebacker Pat Angerer had a game-high 12 tackles.
"I think we all stepped up," Hilton said. "When we lost '87' (Wayne), we knew we all had to come together and just make plays."
The Rams were unable to give the Colts some help last weekend, falling 28-21 to the visiting Titans. That gave St. Louis its third straight loss following a 3-3 start.
Making his second straight start in place of the injured Sam Bradford (knee), Kellen Clemens threw for 210 yards and a touchdown on 20-of-35 passing, but his late fumble helped set up Tennessee's go-ahead score with 2:54 to play.
"We turned it over twice to a good running football team like that that's playing good defense," said Fisher. "It's hard to win. Now granted, we got (turnovers), but we didn't take advantage of them."
Zac Stacey continued his breakout performance out of the backfield with a pair of rushing touchdowns and 127 yards on the ground while adding six receptions for 51 yards.
Jared Cook also recorded a TD reception in defeat, while cornerback Cortland Finnegan and safety Rodney McLeod had interceptions.
The Rams are set to visit the Colts for the first time since the 2005 season and Indianapolis has won two straight and three of the previous four meetings.
The Colts lead the all-time series 23-17-2.