New Orleans, LA (Sports Network) - Colin Kaepernick threw for a touchdown and ran for another, while Ahmad Brooks and Donte Whitner each returned an interception for a score as the San Francisco 49ers downed the New Orleans Saints, 31-21.
Kaepernick completed 16-of-25 passes for 231 yards with the touchdown and an interception in his second career start in place of Alex Smith.
Smith suffered a concussion during the 49ers' 24-24 tie against the St. Louis Rams two weeks ago, and although Smith was cleared for contact earlier this week, Kaepernick remained the starter for San Francisco (8-2-1).
Kaepernick finished with 27 yards and a touchdown on six carries and Frank Gore added 83 yards on 19 totes in the 49ers' second straight win.
Drew Brees threw for 267 yards, three touchdowns and two interceptions on 26- for-41 efficiency for the Saints (5-6), but was mainly kept in check by a 49ers defense that racked up five sacks.
Marques Colston became the Saints' all-time leader in touchdowns and finished with 36 yards and a score on four receptions as New Orleans had its three-game win streak snapped.