ST. LOUIS (KSDK) - Busch Stadium will host its first ever NCAA college football game this fall.

The Southeast Missouri State Redhawks will take on the Salukis of Southern Illinois September 21. Kickoff is scheduled for 1 p.m.

Both schools have approximately 40,000 alumni in St. Louis, and thousands of students in the region as well.

This will be the 81st game between Southeast Missouri State and Southern Illinois University.

Tickets go sale June 3 with prices starting at $10. For more information on the game, or follow "#footballatbusch" on Twitter.

In May, Busch Stadium is hosting an international soccer match between Manchester City and Chelsea of the English Premier League.