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WASHINGTON (CNN) - Drug enforcement officials Wednesday served more than 150 arrest warrants and 375 search warrants in the culmination of a massive, months-long crackdown on synthetic drug rings.

The result is what officials are calling the largest synthetic drug bust ever.

The focus of the DEA-led investigation was so-called designer synthetic drugs, which include synthetic marijuana products like K2 and spice "bath salts" and other drugs that mimic the effects of cocaine, LSD, and crystal meth.

Over the past three days, officials have seized more than 1,200 pounds of the drugs.

Authorities traced the profits from the sale of the designer drugs back to countries around the world, including the Middle East.

The scope of the crackdown spans more than 35 states, 49 cities and five countries.