In the last two decades, the number of overdose deaths of women ages 30 to 64 has more than quadrupled, a CDC study found.

These numbers show women are at risk now more than ever because a lot of the medications are not from the street but from doctors. Drugs like Valium and Xanax.

"It is our moms, our aunts, our grandparents, colleagues the people we go to work out with,” Dr. Jennifer Blumb told NBC Nightly News.

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Experts suggest doctors who are treating women for depression, pain or anxiety may want to consider alternative options.